Need Someone who understands

Hello, My wife was diagnosed with MS 22 years ago, before we met. She told me about it before we really started to date seriously but I had already fallen in love with her so it was not an issue for me. Although I knew a lot about MS, I was not prepared for how rapidly it could progress. Just 4 years into our marriage, everything changed. She became disabled by it and could no longer work. I make a good living so money was not an issue. However other changes started to occur, the mood swings, the memory loss, the complete loss of physical lovemaking, the depression over her inability to do what she used to do, the arguments about my work schedule. In fairness to my work, I do work hard but am not out of the house for 10 or 12 hrs a day. I leave by 9 am and return home by 5 pm so I can make dinner for us and then the dogs. My job requires that I am available to clients by phone or computer until 9 pm but I am home when and if that occurs. We no longer vacation the way we did, 7 of the last 10 years, we had to cancel at the last minute because she was not doing well. Recently she has started to fill her daily boredom with catalog shopping and this has caused some issues because she buys stuff we just do not need. Her abilities continue to go downhill and her mood with them. The long and short of it is that I feel lost at times. I have given up everything that I or we would or used to do..I feel like a prisoner in my own home. There is no one else to help me. My family is hundreds of miles away and her family does not care, her mother lives with us and is absolutely worthless, she does nothing. I will care for her for the rest of my life and will never abandon her but I have been a caregiver for 15 years now and I just feel like I am at my wits end. Thanks for letting me vent and I would appreciate any feedback.